Table of Contents
What is polyethylene glycol used for?
Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass.
What is polyethylene glycol base?
Polyethylene glycols are water-soluble liquids or waxy solids used in cosmetic and pharmaceutical preparations and in the manufacture of emulsifying or wetting agents and lubricants.
What are the properties of polyethylene glycol?
Characteristics of polyethylene glycol It is non-toxic, colorless, inert, odorless, and non-volatile. Also, it is incredibly soluble in water, and organic solvents such as benzene, carbon tetrachloride, and chloroform.
Is polyethylene glycol used as a preservative?
Polyethylene glycol (PEG) (Fig. 5.9) is a nontoxic water-soluble fusogen, which is approved by the FDA. Some PEGs are also currently used as additives in organ preservation solutions before transplantation to limit the damage associated with cold ischemia reperfusion.
Why polyethylene glycol is bad for you?
The Health Concern The primary concern with PEG compounds is that ethylene oxide is used in their production in a process called ethoxylation. This process can cause contamination with ethylene oxide, a chemical associated with multiple kinds of cancer.
What are the long term side effects of polyethylene glycol?
In our study, long-term PEG therapy did not have any major clinical adverse effects. The most common clinical adverse effect was excessively loose or frequent stools that resolved with reduction of the PEG dose. Other adverse effects were minimal and acceptable.
How long does it take for polyethylene glycol to work?
How long does polyethylene glycol take to work? It may take 2 to 4 days before a bowel movement occurs.
How are binders used in binary mixtures?
The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol.
What makes a good binder for a tablet?
The choice of a suitable binder for a tablet formulation requires extensive knowledge of the relative importance of binder properties for enhancing the strength of the tablet and also of the interactions between the various materials constituting a tablet.
How does a binder affect the strength of a compound?
For example, the plasticity and particle size of the binder had the most significant effects on tablet strength when the tablet porosity of the compound was relatively low. A combination of the plasticity and the compactibility of the binder determined the strength of tablets when the tablet of a compound was more porous.
What are the characteristics of a pharmaceutical binder?
Characteristics such as high plasticity, low elasticity and a small particle size were associated with a more even distribution and a consequent pronounced effect on pore structure and marked improvement in tablet strength. The strength of tablets containing less plastic binders was governed more by the compactibility of the binder.